You can attempt a few different things to fix the issue of quickbooks won't open including the following: Your first step should be to restart your computer and give QuickBooks another shot after it has finished loading. Another option is to launch QuickBooks in Safe Mode and see if it helps. If the issue continues to persist, you can try opening QuickBooks using the Selective Startup mode. The final option is to use the QuickBooks Install Diagnostic Tool to perform repairs on QuickBooks.